How Does Protein Corona Affect Nanoparticle Function?
The presence of a protein corona can significantly alter the intended function of a nanoparticle. For instance, it can affect the targeting ability of nanoparticles designed for drug delivery by masking surface ligands that are meant to bind to specific cell receptors. Additionally, the corona can influence the immune response, potentially leading to rapid clearance from the body or, conversely, to unintended accumulation in certain tissues.
