Nanotechnology plays a crucial role in enhancing the efficiency, sensitivity, and accuracy of scRNA-seq. Nanomaterials such as nanoparticles, nanopores, and nanochannels are employed to improve cell capture, lysis, and RNA extraction. For example, magnetic nanoparticles can be used to isolate single cells from complex mixtures, while nanopores allow for high-throughput sequencing by enabling the direct reading of RNA molecules.