Nanotechnology provides several delivery systems that can protect siRNAs from degradation and facilitate their entry into cells. These include:
Lipid Nanoparticles (LNPs): These are one of the most advanced delivery systems for RNAi. LNPs encapsulate siRNAs in a lipid bilayer, protecting them from enzymatic degradation and enhancing cellular uptake. Polymeric Nanoparticles: These are made from biocompatible and biodegradable polymers that can encapsulate siRNAs and release them in a controlled manner. Gold Nanoparticles: These can be functionalized with siRNAs and targeting ligands to improve specificity and efficiency of delivery. Dendrimers: These are highly branched, tree-like structures that can carry multiple siRNA molecules and facilitate their delivery into cells.
