One common method for mass detection at the nanoscale is the use of nanomechanical resonators. These devices operate on the principle of detecting changes in their resonant frequency when a mass is added or removed. The change in frequency can be correlated to the mass of the particle or molecule. Another popular technique is Quartz Crystal Microbalance (QCM), which measures changes in the frequency of a quartz crystal resonator as mass is deposited on its surface.
