How Do Nanoparticles Accumulate in Biological Systems?
Nanoparticles can enter biological systems via various routes such as inhalation, ingestion, or through the skin. Once inside the body, they can accumulate in specific organs or tissues due to their size, shape, surface charge, and chemical composition. For example, due to the enhanced permeability and retention (EPR) effect, nanoparticles tend to accumulate more in tumor tissues than in normal tissues.
