Sergei M. Mirkin - Nanotechnology

Author Information

Sergei M. Mirkin is a distinguished researcher affiliated with the Department of Biology at Tufts University, located in Medford, MA, USA. His work primarily revolves around the field of genome stability, with a particular focus on DNA secondary structures and their role in genome instability.

Research Contributions

Sergei M. Mirkin has made significant contributions to the understanding of genome instability, particularly in relation to DNA secondary structures like GAA repeats and G-quadruplexes. His research has elucidated the mechanisms of repeat-mediated genome instability and its implications in diseases such as Friedreich's ataxia. His recent works include studies on the instability of GAA repeats during chronological aging, the impact of Rad9-mediated checkpoint activation on GAA repeat expansions, and the replication-dependent formation of G-quadruplex structures. His insights have advanced the field's understanding of how dynamic DNA structures contribute to genomic instability and have potential implications for cancer research and genetic disorders.

Aliases

Sergei M. Mirkin is also known by several aliases, including S Mirkin, Sergei Mirkin, S. Mirkin, S.m. Mirkin, S. M. Mirkin, and S M Mirkin.

Publication and Citation Metrics

Metric	Value
Total Citations	7760
h-index	45
Number of Papers	138

Publications:

Characteristics and possible mechanisms of formation of microinversions distinguishing human and chimpanzee genomes

DOI: 10.1038/s41598-021-04621-w

Year: 2022

Linking Dynamic DNA Secondary Structures to Genome Instability

DOI: 10.1101/2022.01.19.476973

Year: 2022

Replication-independent instability of Friedreich’s ataxia GAA repeats during chronological aging

DOI: 10.1073/pnas.2013080118

Year: 2021

Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast.

DOI: 10.1093/genetics/iyab125

Year: 2021

Faculty Opinions recommendation of Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling.

DOI: 10.3410/f.740065452.793585364

Year: 2021

On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability.

DOI: 10.1074/jbc.REV119.007678

Year: 2020

On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

DOI: 10.1074/jbc.REV119.007678

Year: 2020

Large-scale contractions of Friedreich’s ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability

DOI: 10.1073/pnas.1913416117

Year: 2020

Faculty Opinions recommendation of Repeat expansions confer WRN dependence in microsatellite-unstable cancers.

DOI: 10.3410/f.738763260.793578988

Year: 2020

Experimental System to Study Instability of (CGG)n Repeats in Cultured Mammalian Cells.

DOI: 10.1007/978-1-4939-9784-8_9

Year: 2020

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