Mark E. Von Zastrow - Nanotechnology

Author Information

Mark E. Von Zastrow is affiliated with the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco, located in San Francisco, CA, USA. His work primarily focuses on the intricate mechanisms of G protein-coupled receptors (GPCRs) and their role in cellular signaling processes.

Research Contributions

Mark E. Von Zastrow has made significant contributions to the field of cellular and molecular pharmacology, particularly in understanding GPCR signaling and endocytic trafficking. His research explores the diversity of agonist-selective effects on GPCRs, the role of membrane phosphoinositides in stabilizing GPCR-arrestin complexes, and the dynamics of cAMP signaling within cells. His work employs advanced techniques such as live-cell imaging, CRISPR interference screens, and high-throughput assays to dissect the regulatory mechanisms governing GPCR/cAMP signaling and their broader impacts on cellular functions.

Aliases

Mark E. Von Zastrow is also known by the aliases M Von Zastrow and Mark Von Zastrow.

Publication and Citation Metrics

Metric	Value
Total Citation Count	18,085
H-index	64
Total Paper Count	143

Publications:

Profiling the diversity of agonist-selective effects on the proximal proteome environment of G protein-coupled receptors

DOI: 10.1101/2022.03.28.486115

Year: 2022

A Live-Cell Imaging Assay for Nuclear Entry of cAMP-Dependent Protein Kinase Catalytic Subunits Stimulated by Endogenous GPCR Activation.

DOI: 10.1007/978-1-0716-2245-2_21

Year: 2022

Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics

DOI: 10.1101/2021.10.09.463790

Year: 2021

Endosomal cAMP production broadly impacts the cellular phosphoproteome

DOI: 10.1101/2021.01.06.425636

Year: 2021

Mechanisms for Regulating and Organizing Receptor Signaling by Endocytosis.

DOI: 10.1146/annurev-biochem-081820-092427

Year: 2021

Spatial decoding of endosomal cAMP signals by a metastable cytoplasmic PKA network

DOI: 10.1038/s41589-021-00747-0

Year: 2021

Glucagon Receptor-mediated Regulation of Gluconeogenic Gene Transcription is Endocytosis-dependent in Primary Hepatocytes

DOI: 10.1101/2021.09.03.458925

Year: 2021

Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells

DOI: 10.7554/eLife.54208

Year: 2020

G protein-regulated endocytic trafficking of adenylyl cyclase type 9

DOI: 10.1101/2020.04.23.057026

Year: 2020

A high-throughput CRISPR interference screen for dissecting functional regulators of GPCR/cAMP signaling

DOI: 10.1371/journal.pgen.1009103

Year: 2020

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