Le-qun Huang - Nanotechnology

Author Information

Leaf Huang is a distinguished researcher affiliated with the Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. His research focuses primarily on nanotechnology and its applications in drug delivery systems, cancer therapy, and immunotherapy.

Research Contributions

Leaf Huang has made significant contributions to the field of nanotechnology, particularly in the areas of drug delivery and cancer therapy. His recent works include the development of Magnolol-loaded Cholesteryl Biguanide Conjugate Hydrochloride Nanoparticles for triple-negative breast cancer therapy, strategies targeting tumor immune and stromal microenvironment, and the nano delivery of simvastatin to remodel tumor microenvironment for hepatocellular carcinoma. He has also explored minimalist binary vaccine carriers for personalized postoperative cancer vaccine therapy, and his research on nano-trapping CXCL13 aims to reduce regulatory B cells in tumor microenvironments. His work is characterized by its innovative approach to leveraging nanotechnology for therapeutic purposes.

Aliases

Leaf Huang is also known by the aliases Le-qun Huang and Lea Huang.

Publication and Citation Metrics

Metric	Value
Total Citation Count	39,937
h-index	108
Total Paper Count	491

Publications:

Magnolol-loaded Cholesteryl Biguanide Conjugate Hydrochloride Nanoparticles for Triple-negative Breast Cancer Therapy.

DOI: 10.1016/j.ijpharm.2022.121509

Year: 2022

Strategies targeting tumor immune and stromal microenvironment and their clinical relevance.

DOI: 10.1016/j.addr.2022.114137

Year: 2022

Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma

DOI: 10.1186/s12951-021-01205-8

Year: 2022

A Minimalist Binary Vaccine Carrier for Personalized Postoperative Cancer Vaccine Therapy

DOI: 10.1002/adma.202109254

Year: 2022

Nano-trapping CXCL13 reduces regulatory B cells in tumor microenvironment and inhibits tumor growth.

DOI: 10.1016/j.jconrel.2022.01.039

Year: 2022

mRNA vaccine for cancer immunotherapy

DOI: 10.1186/s12943-021-01335-5

Year: 2021

Nanodrug Delivery Systems Modulate Tumor Vessels to Increase the Enhanced Permeability and Retention Effect

DOI: 10.3390/jpm11020124

Year: 2021

The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1

DOI: 10.1126/sciadv.abg9241

Year: 2021

Two nanoformulations induce reactive oxygen species and immunogenetic cell death for synergistic chemo-immunotherapy eradicating colorectal cancer and hepatocellular carcinoma

DOI: 10.1186/s12943-020-01297-0

Year: 2021

Corrigendum to "Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy" [Biomaterials 269 (2021) 120604].

DOI: 10.1016/j.biomaterials.2021.121121

Year: 2021

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