Superparamagnetic Iron Oxide Nanoparticles (SPIONs) - Nanotechnology

What are Superparamagnetic Iron Oxide Nanoparticles (SPIONs)?

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are a class of nanoparticles that exhibit superparamagnetic properties, which means they can be magnetized in the presence of an external magnetic field and demagnetized when the field is removed. These nanoparticles typically range from 1 to 100 nanometers in size and consist primarily of iron oxide compounds such as magnetite (Fe3O4) and maghemite (γ-Fe2O3).

Why are SPIONs Important in Nanotechnology?

SPIONs have garnered significant interest in nanotechnology due to their unique magnetic properties, biocompatibility, and potential for functionalization. Their ability to be controlled via magnetic fields makes them ideal for various biomedical applications, including drug delivery, magnetic resonance imaging (MRI), and hyperthermia treatment for cancer.

How are SPIONs Synthesized?

Several methods exist for the synthesis of SPIONs, including co-precipitation, thermal decomposition, and hydrothermal synthesis. Each method has its advantages and limitations. For instance, co-precipitation is a relatively simple and cost-effective method, but it might not offer the high control over particle size and shape that thermal decomposition provides. The choice of synthesis method often depends on the intended application and required particle characteristics.

What are the Applications of SPIONs in Medicine?

Magnetic Resonance Imaging (MRI)
One of the most well-established applications of SPIONs is in MRI as contrast agents. Their superparamagnetic properties enhance the contrast between different tissues, improving the quality of the imaging. SPIONs are particularly useful for imaging soft tissues like the brain and liver.

Drug Delivery
SPIONs can be functionalized with various drugs and targeted to specific sites within the body using an external magnetic field. This targeted delivery minimizes the side effects of drugs and enhances their therapeutic efficacy. For example, SPIONs have been explored for delivering chemotherapeutic agents directly to tumor sites.

Hyperthermia Treatment

Relevant Publications

Reconstruction of TNF-α with specific isoelectric point released from SPIONs basing on variable charge to enhance pH-sensitive controlled-release.

Issue Release: 2024

In vitro and in vivo evaluation of biohybrid tissue-engineered vascular grafts with transformative H/F MRI traceable scaffolds.

Issue Release: 2024

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile.

Issue Release: 2024

Advancing MRI with magnetic nanoparticles: a comprehensive review of translational research and clinical trials.

Issue Release: 2024

One-Step Preparation of Magnetic Lipid Bubbles: Magnetothermal Effect Induces the Simultaneous Formation of Gas Nuclei and Self-Assembly of Phospholipids.

Issue Release: 2024

Advances in superparamagnetic iron oxide nanoparticles modified with branched polyethyleneimine for multimodal imaging.

Issue Release: 2024

Improved Methodology for Evaluating Nanomedicine Antibacterial Properties in Biological Fluids.

Issue Release: 2024

A Benchtop Round Window Model for Studying Magnetic Nanoparticle Transport to the Inner Ear.

Issue Release: 2024

Green synthesis of Superparamagnetic Iron Oxide and Silver Nanoparticles in Satureja hortensis Leave Extract: Evaluation of Antifungal Effects on Botryosphaeriaceae Species.

Issue Release: 2024

Increased endocytosis rate and enhanced lysosomal pathway of silica-coated superparamagnetic nanoparticles into M-HeLa cells compared with cultured primary motor neurons.

Issue Release: 2024

Superparamagnetic Iron Oxide Nanoparticles Reprogram the Tumor Microenvironment and Reduce Lung Cancer Regrowth after Crizotinib Treatment.

Issue Release: 2024

The corrective role of superparamagnetic iron oxide nanoparticles for the genes controlling hypothalamus-pituitary-testis-axis in male obesity-associated secondary hypogonadism.

Issue Release: 2024

Anticancer therapeutic potential of multimodal targeting agent- \"phosphorylated galactosylated chitosan coated magnetic nanoparticles\" against N-nitrosodiethylamine-induced hepatocellular carcinoma.

Issue Release: 2024

Low-cost one-pot synthesis of hydrophobic and hydrophilic monodispersed iron oxide nanoparticles.

Issue Release: 2024

Targeted mitigation of neointimal hyperplasia via magnetic field-directed localization of superparamagnetic iron oxide nanoparticle-labeled endothelial progenitor cells following carotid balloon catheter injury in rats.

Issue Release: 2024

Infection-Sensitive SPION/PLGA Scaffolds Promote Periodontal Regeneration via Antibacterial Activity and Macrophage-Phenotype Modulation.

Issue Release: 2024

Improving MPI and hyperthermia performance of superparamagnetic iron oxide nanoparticles through fractional factorial design of experiments.

Issue Release: 2024

Simultaneous therapeutic and diagnostic applications of magnetic PLGA nanoparticles loaded with doxorubicin in rabbit.

Issue Release: 2024

Green Dentistry in Oral Cancer Treatment Using Biosynthesis Superparamagnetic Iron Oxide Nanoparticles: A Systematic Review.

Issue Release: 2024

Development of high-efficiency superparamagnetic drug delivery system with MPI imaging capability.

Issue Release: 2024

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