poly(glycolic acid) - Nanotechnology

What is Poly(glycolic acid)?

Poly(glycolic acid) (PGA) is a biodegradable, thermoplastic polymer known for its high mechanical strength and biodegradability. It is commonly used in medical applications such as sutures, drug delivery systems, and tissue engineering scaffolds.

Why Use Poly(glycolic acid) in Nanotechnology?

PGA's biocompatibility and biodegradability make it an excellent candidate for nanotechnology applications. Its ability to degrade into non-toxic metabolites (glycolic acid) is particularly advantageous for medical and environmental applications.

Applications in Drug Delivery

One of the most significant applications of PGA in nanotechnology is in nanoparticle-based drug delivery systems. PGA nanoparticles can encapsulate drugs, protecting them from degradation and allowing for controlled release at the target site. This can improve the efficacy and reduce the side effects of many therapeutics.

Applications in Tissue Engineering

PGA is also widely used in tissue engineering. Its high tensile strength and biodegradability make it an ideal material for scaffolds that support cell growth and tissue regeneration. Nanostructured PGA scaffolds can mimic the extracellular matrix, promoting cell adhesion, proliferation, and differentiation.

Environmental Applications

Beyond medical applications, PGA can also be utilized in environmental nanotechnology. For example, PGA nanoparticles can be used in biodegradable packaging materials, reducing plastic waste and promoting sustainability.

Challenges and Future Directions

Despite its many advantages, PGA has some limitations, such as its rapid degradation rate and potential for inflammation in some cases. Researchers are working to modify the polymer's properties through copolymerization and surface modification techniques to overcome these challenges.

Conclusion

Poly(glycolic acid) offers a range of exciting possibilities in the field of nanotechnology, from drug delivery to tissue engineering and environmental sustainability. Continued research and development will likely expand its applications and improve its performance in various fields.

Relevant Publications

Sustained release of inactivated H1N1 virus from degradable microparticles for extended vaccination.

Issue Release: 2024

Targeting tumor-associated macrophage with mannosylated nanotherapeutics delivering TLR7/8 agonist enhances cancer immunotherapy.

Issue Release: 2024

Sustained release system from PLGA particles co-encapsulated with inactivated influenza virus with natural killer T cell agonist α-galactosylceramide.

Issue Release: 2024

Development, Optimization, and in vitro Evaluation of Silybin-loaded PLGA Nanoparticles and Decoration with 5TR1 Aptamer for Targeted Delivery to Colorectal Cancer Cells.

Issue Release: 2024

In vitro and in vivo evaluation of biohybrid tissue-engineered vascular grafts with transformative H/F MRI traceable scaffolds.

Issue Release: 2024

In situ comparison of osteogenic effects of polymer-based scaffolds with different degradability by integrated scaffold model.

Issue Release: 2024

Nanospheres for curcumin delivery as a precision nanomedicine in cancer therapy.

Issue Release: 2024

Design of Experiment (DoE) Approach for Developing Inhalable PLGA Microparticles Loaded with Clofazimine for Tuberculosis Treatment.

Issue Release: 2024

In Vitro and In Vivo Drug Release from a Nano-Hydroxyapatite Reinforced Resorbable Nanofibrous Scaffold for Treating Female Pelvic Organ Prolapse.

Issue Release: 2024

Development and evaluation of ursolic acid-loaded poly(lactic--glycolic acid) nanoparticles in cholangiocarcinoma.

Issue Release: 2024

Ti3C2Tx@PLGA/Icaritin microspheres-modified PLGA/β-TCP scaffolds modulate Icaritin release to enhance bone regeneration through near-infrared response.

Issue Release: 2024

Advancements in Curcumin-Loaded PLGA Nanoparticle Delivery Systems: Progressive Strategies in Cancer Therapy.

Issue Release: 2024

PLGA-PEG-COOH nanoparticles are efficient systems for delivery of mefloquine to Echinococcus multilocularis metacestodes.

Issue Release: 2024

PLGA and PDMS-based forming implants loaded with rosuvastatin and copper-selenium nanoparticles: a promising dual-effect formulation with augmented antimicrobial and cytotoxic activity in breast cancer cells.

Issue Release: 2024

Intra-articular injection of an extended-release flavopiridol formulation represents a potential alternative to other intra-articular medications for treating equine joint disease.

Issue Release: 2024

Design and in vitro evaluation of curcumin-loaded PLGA nanoparticle embedded sodium alginate/gelatin 3D printed scaffolds for Alzheimer\'s disease.

Issue Release: 2024

Neuro-Immunomodulatory Potential of Nanoenabled 4D Bioprinted Microtissue for Cartilage Tissue Engineering.

Issue Release: 2024

Enhanced Reendothelialization and Thrombosis Prevention with a New Drug-Eluting Stent.

Issue Release: 2024

Rescuing a Troubled Tolcapone with PEGylated PLGA Nanoparticles: Design, Characterization, and Hepatotoxicity Evaluation.

Issue Release: 2024

Preventing Surgical Site Infections with a Nitric Oxide-Releasing Poly(lactic acid--glycolic acid) Suture Material.

Issue Release: 2024

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