Controlled Release - Nanotechnology

What is Controlled Release in Nanotechnology?

Controlled release refers to the precise delivery of substances, such as pharmaceutical drugs, pesticides, or nutrients, over a specific period. In the context of nanotechnology, it involves the use of nanocarriers to encapsulate these substances and release them in a controlled manner at the target site.

How Does Controlled Release Work?

Controlled release systems often utilize polymeric nanoparticles, dendrimers, liposomes, and inorganic nanoparticles. These nanocarriers can be engineered to respond to various stimuli such as pH, temperature, or specific enzymes, allowing the encapsulated substance to be released only under certain conditions, thus increasing the efficacy and reducing side effects.

What Are the Advantages of Controlled Release?

One of the primary benefits is the targeted delivery of drugs, which minimizes systemic side effects and maximizes therapeutic effects. Sustained release of the active substance also means less frequent dosing, improving patient compliance. Additionally, controlled release can protect sensitive substances from degradation before they reach their target.

What Are the Applications of Controlled Release?

Controlled release technologies are used in a variety of fields. In medicine, they enable the targeted treatment of diseases such as cancer, reducing the impact on healthy cells. In agriculture, controlled release of pesticides and fertilizers can lead to more efficient use of resources and reduced environmental impact. In cosmetics, ingredients are delivered over time to provide prolonged benefits.

What Are the Challenges and Limitations?

Despite its advantages, controlled release via nanotechnology faces several challenges. Biocompatibility and toxicity of nanomaterials are significant concerns, as is the potential for accumulation in the body leading to unforeseen side effects. Manufacturing and scalability of these nanocarriers can also be costly and complex.

What is the Future of Controlled Release in Nanotechnology?

Advancements in smart materials and nanofabrication techniques are expected to address many of the current challenges. Future research is likely to focus on developing more efficient, safe, and cost-effective nanocarriers. The integration of artificial intelligence in designing these systems could further enhance their precision and efficacy.

Relevant Publications

Controlled Release of Molecules to Enhance Cell Survival and Regeneration.

Issue Release: 2025

Fully flexible implantable neural probes for electrophysiology recording and controlled neurochemical modulation.

Issue Release: 2024

Using Microdialysis to Monitor Dopaminergic Support of Limb-Use Control Following Mesencephalic Neurosphere Transplantation in a Rodent Model of Parkinson\'s Disease.

Issue Release: 2024

Long duration sodium hyaluronate hydrogel with dual functions of both growth prompting and acid-triggered antibacterial activity for bacteria-infected wound healing.

Issue Release: 2024

MgSiO Fiber Membrane Scaffold with Triggered Drug Delivery for Osteosarcoma Synergetic Therapy and Bone Regeneration.

Issue Release: 2024

Fabrication of pH-responsive temozolomide (TMZ)-clacked tannic acid-altered zeolite imidazole nanoframeworks (ZIF-8) enhance anticancer activity and apoptosis induction in glioma cancer cells.

Issue Release: 2024

Application of slow-controlled release fertilizer coordinates the carbon flow in carbon-nitrogen metabolism to effect rice quality.

Issue Release: 2024

Evaluation of microwave irradiated Polyacrylamide grafted Opuntia leaf mucilage graft copolymer (OPM-g-PAM) as effective controlled release polymer for release of Rosuvastastin as model drug.

Issue Release: 2024

Design and evaluation of fluorescent chitosan-starch hydrogel for drug delivery and sensing applications.

Issue Release: 2024

A photoactivatable upconverting nanodevice boosts the lysosomal escape of PROTAC degraders for enhanced combination therapy.

Issue Release: 2024

Biofilm microenvironment-activated multimodal therapy nanoplatform for effective anti-bacterial treatment and wound healing.

Issue Release: 2024

A Landscape of Methodology and Implementation of Adaptive Designs in Cancer Clinical Trials.

Issue Release: 2024

Developments in anticorrosive organic coatings modulated by nano/microcontainers with porous matrices.

Issue Release: 2024

Efficacy and safety of Ferrous iron on the prevention of Vascular cOgnitive impaiRment among patients with cerebral Infarction/TIA (FAVORITE): rationale and design of a multicentre randomised trial.

Issue Release: 2024

Does metformin prolong pregnancy in preterm pre-eclampsia? A study protocol for a South African, hospital-based double-blind, randomised, placebo-controlled trial.

Issue Release: 2024

Growth factor-functionalized titanium implants for enhanced bone regeneration: A review.

Issue Release: 2024

Nano bio fertilizer capsules for sustainable agriculture.

Issue Release: 2024

Ultrasound-triggered functional hydrogel promotes multistage bone regeneration.

Issue Release: 2024

Does selective intraoperative music reduce pain following abdominal wall reconstruction? A double-blind randomized controlled trial.

Issue Release: 2024

Scaffold-Mediated Drug Delivery for Enhanced Wound Healing: A Review.

Issue Release: 2024

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