Acetylcholinesterase - Nanotechnology

What is Acetylcholinesterase?

Acetylcholinesterase (AChE) is a crucial enzyme in the nervous system responsible for breaking down the neurotransmitter acetylcholine into choline and acetate. This process is vital for terminating synaptic transmission and ensuring proper muscular function and cognitive processes.

Why is Acetylcholinesterase Important in Nanotechnology?

AChE has gained significant attention in the field of nanotechnology due to its potential applications in biosensing, drug delivery, and environmental monitoring. Its high specificity and catalytic efficiency make it a suitable candidate for developing advanced nanodevices and nanomaterials.

How Can Nanotechnology Enhance the Function of Acetylcholinesterase?

Nanotechnology can enhance AChE's function through immobilization on nanoparticles, which can increase its stability, activity, and reusability. Nanocarriers can also be employed to deliver AChE in a controlled manner, improving its therapeutic efficacy in treating neurological disorders such as Alzheimer's disease.

What are the Applications of AChE in Nanotechnology?

Applications of AChE in nanotechnology include:

Biosensors: AChE-based nanobiosensors are used for detecting pesticides and nerve agents by measuring the inhibition of the enzyme.
Drug Delivery: AChE can be loaded onto nanocarriers for targeted delivery in the treatment of neurological diseases, enhancing drug efficiency and reducing side effects.
Environmental Monitoring: AChE immobilized on nanomaterials can detect and quantify environmental pollutants, providing a rapid and sensitive analytical tool.

What are the Challenges in Using Acetylcholinesterase in Nanotechnology?

Despite the promising applications, there are challenges in using AChE in nanotechnology:

Enzyme Stability: Maintaining the stability and activity of AChE when immobilized on nanoparticles can be challenging.
Biocompatibility: Ensuring that the nanomaterials used are biocompatible and do not induce adverse biological responses is critical.
Scalability: Developing scalable and cost-effective methods for synthesizing AChE-based nanodevices is essential for their widespread application.

Future Directions and Research

Future research is focused on developing more robust and efficient AChE-based nanomaterials. Innovations in nanofabrication techniques and bioconjugation methods could significantly enhance the performance and applicability of AChE in various fields. Additionally, exploring new nanocarriers and hybrid materials may provide more effective solutions for diagnostic and therapeutic applications.

Relevant Publications

Phenolic content of Thai Bao mango peel and its antioxidant, anti-cholinesterase, and antidiabetic activities.

Issue Release: 2024

Acetylcholinesterase and dopamine inhibition suppress the filtration rate, burrowing behaviours, and immunological responses induced by bisphenol A in the hemocytes and gills of date mussels, Lithophaga lithophaga.

Issue Release: 2024

Assessment of triclosan induced histopathological and biochemical alterations, and molecular docking simulation analysis of acetylcholinesterase enzyme in the gills of fish, Cyprinus carpio.

Issue Release: 2024

Oxime-functionalized anti-insecticide fabric reduces insecticide exposure through dermal and nasal routes, and prevents insecticide-induced neuromuscular-dysfunction and mortality.

Issue Release: 2024

Exposure to pesticides used in rice farming (bentazone, chlorantraniliprole and tebuconazole) affects biochemical biomarkers and hepatic histopathological parameters of hammertoad tadpoles (Boana faber).

Issue Release: 2024

Metal-contaminated sediment toxicity in a highly impacted Neotropical River: Insights from zebrafish embryo toxicity assays.

Issue Release: 2024

Metabolic profiling of Vitex Pubescens Vahl bark via UPLC-ESI-QTOF/MS/MS analysis and evaluation of its antioxidant and acetylcholinesterase inhibitory activities.

Issue Release: 2024

[Establishment of a rapid detection method of colloidal gold immunochromatographic competition assay for organophosphorus pesticides].

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Language impairments in Alzheimer´s disease: What changes can be found between mild and moderate stages of the disease?

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Neurotoxic and Cardiotoxic Effects of Pyrogallol on catfish (Clarias gariepinus).

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Amine-containing donepezil analogues as potent acetylcholinesterase inhibitors with increased polarity.

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Ameliorative effect of vanillic acid against scopolamine-induced learning and memory impairment in rat via attenuation of oxidative stress and dysfunctional synaptic plasticity.

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Toxicity assessment of 3-O-[6-deoxy-3-O-methyl-β-D-allopyranosyl-(1→4)-β-D-oleandropyranosyl]-17β-marsdenin isolated from Gongronema latifolium leaf on selected brain and kidney function indices in mice.

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Reactivation by novel pyridinium oximes of rat serum and skeletal muscle acetylcholinesterase inhibited by organophosphates.

Issue Release: 2024

Quaternity method for integrated screening, separation, extraction optimization, and bioactivity evaluation of acetylcholinesterase inhibitors from Sophora flavescens Aiton.

Issue Release: 2024

Distinct synaptic mechanisms drive the behavioral response to acute stress and rapid correction by ketamine.

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Synthesis, biological evaluation, theoretical calculations, QSAR and molecular docking studies of novel arylaminonaphthols as potent antioxidants and BChE inhibitors.

Issue Release: 2024

Neolignans in Magnolia officinalis as natural anti-Alzheimer\'s disease agents: A systematic review.

Issue Release: 2024

Succinimide Derivatives as Acetylcholinesterase Inhibitors-In Silico and In Vitro Studies.

Issue Release: 2024

New Heterostilbene and Triazole Oximes as Potential CNS-Active and Cholinesterase-Targeted Therapeutics.

Issue Release: 2024

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