Wilfred Ching-ching Chen - Nanotechnology

Author Information

Wilfred Chen is affiliated with the Department of Chemical and Biomolecular Engineering at the University of Delaware, located at 150 Academy Street, Newark, DE 19716, USA. His research focuses on nanotechnology and its biomedical applications, particularly in targeted drug delivery, gene expression modulation, and enzyme activity regulation.

Research Contributions

Wilfred Chen has made significant contributions to the field of nanotechnology and its application in biomedicine. His recent work includes the development of EGFR ligand clustering on E2 bionanoparticles for targeted delivery of chemotherapeutics to breast cancer cells, and deciphering design rules for toehold-gated sgRNA for conditional gene expression and protein degradation in mammalian cells. Other notable research includes the incorporation of endosomolytic peptides into EGFR-targeted protein conjugates, dynamic modulation of enzyme activity by synthetic CRISPR-Cas6 endonucleases, and engineering bionanoparticles for improved biosensing and bioimaging. Chen has also reviewed the applications of outer membrane vesicles (OMVs) and contributed to advancements in cell surface display technologies for directed protein evolution.

Aliases

Wilfred Chen is also known by the aliases Wilfred Chen* and Wilfred Ching-ching Chen.

Publication and Citation Metrics

Citation Count	13,963
h-index	68
Paper Count	303

Publications:

EGFR Ligand Clustering on E2 Bionanoparticles for Targeted Delivery of Chemotherapeutics to Breast Cancer Cells.

DOI: 10.1021/acs.bioconjchem.1c00579

Year: 2022

Deciphering the Design Rules of Toehold-Gated sgRNA for Conditional Activation of Gene Expression and Protein Degradation in Mammalian Cells.

DOI: 10.1021/acssynbio.1c00479

Year: 2022

Incorporation of Endosomolytic Peptides with Varying Disruption Mechanisms into EGFR-Targeted Protein Conjugates: The Effect on Intracellular Protein Delivery and EGFR Specificity in Breast Cancer Cells.

DOI: 10.1021/acs.molpharmaceut.1c00788

Year: 2022

Dynamic modulation of enzyme activity by synthetic CRISPR–Cas6 endonucleases

DOI: 10.1038/s41589-022-01005-7

Year: 2022

Outer membrane vesicles (OMVs) enabled bio‐applications: A critical review

DOI: 10.1002/bit.27965

Year: 2021

Engineering a Blue Light Inducible SpyTag System (BLISS).

DOI: 10.1021/jacs.1c03198

Year: 2021

Engineering bionanoparticles for improved biosensing and bioimaging.

DOI: 10.1016/j.copbio.2021.06.002

Year: 2021

Recent Advances in Cell Surface Display Technologies for Directed Protein Evolution

DOI: 10.1002/9783527815128.ch4

Year: 2021

Self‐assembling protein nanocages for modular enzyme assembly by orthogonal bioconjugation

DOI: 10.1002/btpr.3190

Year: 2021

Synthesis of gold nanostructures using glycine as the reducing agent.

DOI: 10.1088/1361-6528/abaa76

Year: 2020

What is Ion Plating?

What are the Applications of Spin in Nanotechnology?

What are the Benefits of Using Nanotechnology in Anti-inflammatory Treatments?

Why is Material Synthesis Important?

How Does Nanotechnology Improve Signal Processing?

What are the Limited Advanced Functionalities?

Why is Spin Injection Efficiency Important?

What is Single Molecule Detection?

How are Nanoscale Semiconductor Particles Synthesized?

What are the Current Approaches to Encryption in Nanotechnology?

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