What is the Stratum Corneum?
The
stratum corneum is the outermost layer of the epidermis, primarily composed of dead keratinized cells. It acts as a barrier to protect underlying tissues from infection, dehydration, chemicals, and mechanical stress.
Lipid-based nanoparticles: These can merge with the lipid bilayers of the stratum corneum, enhancing permeability.
Polymeric nanoparticles: These can be designed to interact with the stratum corneum's proteins, enhancing drug penetration.
Gold nanoparticles: Due to their small size and surface properties, they can penetrate the stratum corneum and deliver therapeutic agents.
Enhanced drug delivery: Nanoparticles can improve the bioavailability of drugs by crossing the stratum corneum.
Targeted delivery: Nanoparticles can be engineered to release drugs at specific sites, reducing side effects.
Controlled release: Nanotechnology can provide sustained and controlled release of drugs.
Toxicity: The long-term effects of nanoparticles on human health are not fully understood.
Regulatory issues: The regulatory framework for nanoparticles in drug delivery is still evolving.
Stability: Ensuring the stability of nanoparticles in different environmental conditions can be challenging.
Future Directions
The future of stratum corneum disruption through nanotechnology looks promising with ongoing research focusing on: Developing safer and more efficient nanoparticles.
Understanding the long-term effects of nanoparticle exposure.
Creating more personalized and targeted delivery systems.
