Protein Structure - Nanotechnology

What is Protein Structure?

Proteins are large, complex molecules that play many critical roles in biological systems. They are made up of amino acids and have distinct primary, secondary, tertiary, and quaternary structures. Each level of structure is crucial for the protein’s functionality.

Why is Protein Structure Important in Nanotechnology?

Understanding protein structure is essential in nanotechnology for several reasons. Proteins can serve as natural nanomachines, catalysts, and structural components. Leveraging their unique properties enables the development of nanomaterials, biosensors, and targeted drug delivery systems.

How Do Nanotechnologists Study Protein Structure?

Nanotechnologists use various techniques to study protein structures, such as X-ray crystallography, nuclear magnetic resonance (NMR) spectroscopy, and cryogenic electron microscopy (cryo-EM). These methods provide detailed insights into the atomic arrangement of proteins, which is critical for designing nanodevices.

What are the Applications of Protein-based Nanotechnology?

Protein-based nanotechnology has multiple applications, including:

Drug Delivery: Using protein structures to create nanoparticles that can deliver drugs precisely to target cells.
Diagnostics: Developing biosensors that use proteins to detect specific molecules related to diseases.
Nanofabrication: Utilizing proteins to create nanoscale materials and devices with high precision.

What Challenges Exist in Using Proteins for Nanotechnology?

Several challenges exist in using proteins for nanotechnology, including:

Stability: Proteins can be sensitive to environmental conditions, which can affect their stability and functionality.
Complexity: The intricate nature of protein folding and interactions can make their manipulation difficult.
Scalability: Producing protein-based nanodevices on a large scale can be challenging.

Future Prospects

The future of protein-based nanotechnology is promising. Advances in computational modeling and synthetic biology are paving the way for the design of novel proteins with enhanced properties. Additionally, breakthroughs in bioconjugation techniques and nanofabrication methods are set to expand the scope and efficiency of protein-based applications in nanotechnology.

Relevant Publications

Identification of a conserved G-quadruplex within the E165R of African swine fever virus (ASFV) as a potential antiviral target.

Issue Release: 2024

Impact of age on the digestion of cream cheese formulated with opposite caseins to whey proteins ratios: An in vitro study.

Issue Release: 2024

14-3-3 Family of Proteins: Biological Implications, Molecular Interactions, and Potential Intervention in Cancer, Virus and Neurodegeneration Disorders.

Issue Release: 2024

Discovery of GPR84 Fluorogenic Probes Based on a Novel Antagonist for GPR84 Bioimaging.

Issue Release: 2024

Molecular insight into the potential functional role of pseudoenzyme GFOD1 via interaction with NKIRAS2.

Issue Release: 2024

Structure-Guided Engineering of Thermodynamically Enhanced SaCas9 for Improved Gene Suppression.

Issue Release: 2024

Split intein-mediated backbone cyclization enhances the stability and activity of staphylokinase, a potent fibrin-selective plasminogen activator.

Issue Release: 2024

A Chromosome-level Genome Assembly Provides Insights into the Local Adaptation of Tamarix austromongolica in the Yellow River Basin, China.

Issue Release: 2024

Digestion behavior of plant-based meat analogs with anisotropic fibrous structure in a semi-dynamic gastric digestion system.

Issue Release: 2024

Delivery of CRISPR/Cas9 system by AAV as vectors for gene therapy.

Issue Release: 2024

Kinetic and structural characterization of NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis.

Issue Release: 2024

3-chloro-1,2-propanediol induces oxidative stress and promotes testicular damage and infertility in rats through CYP2C9.

Issue Release: 2024

GSK3: A potential target and pending issues for treatment of Alzheimer\'s disease.

Issue Release: 2024

Evaluating representation learning on the protein structure universe.

Issue Release: 2024

Towards a dependable data set of structures for L-asparaginase research.

Issue Release: 2024

Comprehensive approach to in silico identification and in vitro validation of anti-filarial hit molecules targeting the dimer interface of thioredoxin peroxidase 1 in Wuchereria bancrofti: a progress in anti-filariasis drug development.

Issue Release: 2024

Effects of adding proteins from different sources during heat-moisture treatment on corn starch structure, physicochemical and in vitro digestibility.

Issue Release: 2024

Enhancing insulin stability via efficacy chemical modifications: A comprehensive review.

Issue Release: 2024

Incorporation of germinated lupin into corn-based extrudates: Focus on starch digestibility, matrix structure and physicochemical properties.

Issue Release: 2024

A high-affinity, cis-on photoswitchable beta blocker to optically control β-adrenergic receptors in vitro and in vivo.

Issue Release: 2024

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