Liposomal Nanoparticles - Nanotechnology

What are Liposomal Nanoparticles?

Liposomal nanoparticles are spherical vesicles with a phospholipid bilayer, used in nanotechnology for drug delivery and other biomedical applications. These nanoparticles are characterized by their ability to encapsulate both hydrophilic and hydrophobic substances, making them highly versatile in transporting therapeutic agents.

How are Liposomal Nanoparticles Created?

They are typically created through methods such as thin-film hydration, sonication, and extrusion. The process involves hydrating a thin film of lipids in an aqueous solution, followed by sonication or extrusion to achieve the desired size and uniformity.

What are the Applications of Liposomal Nanoparticles?

Liposomal nanoparticles have a wide range of applications including targeted drug delivery, gene therapy, and vaccine delivery. They enhance the efficacy of drugs by improving their solubility, stability, and bioavailability. Additionally, they can help in reducing the toxicity of drugs by ensuring targeted delivery to specific cells or tissues.

Advantages of Liposomal Nanoparticles

One of the primary advantages is their biocompatibility and biodegradability. The phospholipid bilayer is similar to cell membranes, reducing the risk of immune response. Furthermore, they offer controlled and sustained release of therapeutic agents, which can improve treatment outcomes and patient compliance.

Challenges and Limitations

Despite their advantages, liposomal nanoparticles face challenges such as stability issues and manufacturing complexities. The cost of producing liposomal formulations can be high, and their stability during storage and transit needs careful management to prevent leakage or aggregation.

Future Prospects

The future of liposomal nanoparticles looks promising with ongoing research aimed at overcoming current limitations. Innovations like stimuli-responsive liposomes and multi-functional liposomes are being explored to enhance their efficacy and broaden their application scope. Additionally, advancements in nanotechnology and biomedical engineering are expected to drive the development of next-generation liposomal nanoparticles.

Relevant Publications

Liposome-based hybrid drug delivery systems with DNA nanostructures and metallic nanoparticles.

Issue Release: 2024

Polyphenols: Secondary Metabolites with a Biological Impression.

Issue Release: 2024

Role and uptake of metal-based nanoconstructs as targeted therapeutic carriers for rheumatoid arthritis.

Issue Release: 2024

Light Sensitive Liposomes: A Novel Strategy for Targeted Drug Delivery.

Issue Release: 2024

Preparation of Budesonide-Loaded Liposomal Nanoparticles for Pulmonary Delivery and Their Therapeutic Effect in OVA-Induced Asthma in Mice.

Issue Release: 2024

Development of PET Radioisotope Copper-64-Labeled Theranostic Immunoliposomes for EGFR Overexpressing Cancer-Targeted Therapy and Imaging.

Issue Release: 2024

PEGylated-liposomal astaxanthin ameliorates Aβ neurotoxicity and Alzheimer-related phenotypes by scavenging formaldehyde.

Issue Release: 2024

Role of Biofunctionalized Nanoparticles in Digestive Cancer Vaccine Development.

Issue Release: 2024

Sustained release local anesthetics for pain management: relevance and formulation approaches.

Issue Release: 2024

Liposomes to Cubosomes: The Evolution of Lipidic Nanocarriers and Their Cutting-Edge Biomedical Applications.

Issue Release: 2024

Liposomal Phenylephrine Nanoparticles Enhance the Antitumor Activity of Intratumoral Chemotherapy in a Preclinical Model of Melanoma.

Issue Release: 2024

Synthesis of cationic liposome nanoparticles using a thin film dispersed hydration and extrusion method.

Issue Release: 2024

\"Target-and-release\" nanoparticles for effective immunotherapy of metastatic ovarian cancer.

Issue Release: 2024

Facile scalable one-flow synthesis of ionizable cationic lipid library as precursors of nanoparticle carriers.

Issue Release: 2024

Nanoparticles in liposomes: a platform for increased antibiotic selectivity in multidrug resistant bacteria in respiratory tract infections.

Issue Release: 2024

Unraveling the impact of different liposomal formulations on the plasma protein corona composition might give hints on the targeting capability of nanoparticles.

Issue Release: 2024

Development and Evaluation of Methotrexate and Baicalin-Loaded Nanolipid Carriers for Psoriasis Treatment.

Issue Release: 2024

Azobenzene-based liposomes with nanomechanical action for cytosolic chemotherapeutic drug delivery.

Issue Release: 2024

Liposome-encapsulated aprotinin biodistribution in mice: Side-by-side comparison with free drug formulation.

Issue Release: 2024

Model-based meta-analysis to quantify the effects of short interfering RNA therapeutics on hepatitis B surface antigen turnover in hepatitis B-infected mice.

Issue Release: 2024

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