Dosimetry - Nanotechnology

What is Dosimetry in Nanotechnology?

Dosimetry in the context of nanotechnology involves the measurement, calculation, and assessment of the doses received by the human body from exposure to nanomaterials. This is crucial for understanding the potential health risks and ensuring safety in environments where nanomaterials are utilized or synthesized.

Why is Dosimetry Important in Nanotechnology?

Nanomaterials have unique properties due to their small size and large surface area, which can lead to different biological interactions compared to bulk materials. Accurate dosimetry helps in assessing the toxicity and exposure levels, thus guiding safe handling procedures and regulations.

How is Dosimetry Measured in Nanotechnology?

Dosimetry in nanotechnology can be measured using various methods, including:

Direct methods: These involve measuring the concentration of nanomaterials in the air or on surfaces using instruments like Scanning Mobility Particle Sizer (SMPS) or Transmission Electron Microscopy (TEM).
Indirect methods: These involve assessing the biological uptake and distribution of nanomaterials through techniques like mass spectrometry or Inductively Coupled Plasma (ICP).

What are the Challenges in Nanotechnology Dosimetry?

Some of the major challenges include:

Characterizing the physicochemical properties of nanomaterials accurately.
Understanding the biokinetics of nanomaterials in biological systems.
Evaluating the dose-response relationships for different types of nanomaterials.

What are the Current Advances in Nanotechnology Dosimetry?

Recent advances include the development of high-throughput screening methods, in vitro and in vivo models for better assessment of nanomaterial toxicity, and computational modeling techniques to predict exposure and effects.

How Does Dosimetry Influence Regulation and Policy?

Accurate dosimetry data is essential for formulating regulatory guidelines and safety standards. It helps in defining acceptable exposure limits, guiding the design of safer nanomaterials, and ensuring compliance with health and environmental regulations.

Future Directions in Nanotechnology Dosimetry

The future of dosimetry in nanotechnology is likely to involve more interdisciplinary approaches, combining nanotoxicology, epidemiology, and advanced analytical techniques to provide a comprehensive understanding of nanomaterial exposure and risks.

Relevant Publications

Inter-observer effects in needle reconstruction for temporary prostate brachytherapy: Dosimetric implications and adaptive CBCT-TRUS registration solutions.

Issue Release: 2024

Using dose volume histogram (DVH) predictions to improve the plan quality of helical tomotherapy (HT).

Issue Release: 2024

A novel dose rate optimization method to maximize ultra-high dose rate coverage of critical organs-at-risk without compromising dosimetry metrics in proton pencil beam scanning FLASH radiotherapy.

Issue Release: 2024

Central nervous system tumours and occupational ionising radiation exposure: a nested case-control study among the ORICAMs cohort of healthcare workers in France.

Issue Release: 2024

Application and dosimetric comparison of surface-guided deep inspiration breath-hold for lung stereotactic body radiotherapy.

Issue Release: 2024

Long-term outcomes following proton therapy for non-metastatic central nervous system germinoma in children and adolescents.

Issue Release: 2024

Characterization of a commercial plastic scintillator for electron FLASH dosimetry.

Issue Release: 2024

Reading of Gafchromic EBT-3 Film using an Overhead Scanner.

Issue Release: 2024

BC cancer radiation therapists\' perspective on the impact of COVID-19 precautions in clinical practice.

Issue Release: 2024

Comment on the paper: Wang B, Liu Y, Zhang J, Yin S, Liu B, Ding S, Qiu B, Deng X. Evaluating contouring accuracy and dosimetry impact of current MRI-guided adaptive radiation therapy for brain metastases: a retrospective study. J Neurooncol 167(1):123-132, 2024.

Issue Release: 2024

Cross-section of thyroidology and nephrology: Literature review and key points for clinicians.

Issue Release: 2024

A high-throughput focused collimator for OAR-sparing preclinical proton FLASH studies: commissioning and validation.

Issue Release: 2024

Treatment plan complexity quantification for predicting gamma passing rates in patient-specific quality assurance for stereotactic volumetric modulated arc therapy.

Issue Release: 2024

The feasibility of CT simulation-free adaptive radiation therapy.

Issue Release: 2024

Exploring and validating heating dynamics in a radio-frequency electromagnetic field-based resonant chamber for mouse hyperthermia research.

Issue Release: 2024

Evaluation of PET/CT imaging with [89Zr]Zr-DFO-girentuximab: a phase 1 clinical study in Japanese patients with renal cell carcinoma (Zirdac-JP).

Issue Release: 2024

In vivo EPID-based daily treatment error identification for volumetric-modulated arc therapy in head and neck cancers with a hierarchical convolutional neural network: a feasibility study.

Issue Release: 2024

Joint EURADOS-EANM initiative for an advanced computational framework for the assessment of external dose rates from nuclear medicine patients.

Issue Release: 2024

The Royal College of Radiologists National Vulvar Cancer Audit.

Issue Release: 2024

In Vitro Gamma Mutagenesis Techniques in Rice (Oryza sativa L. var. Lazarroz FL).

Issue Release: 2024

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