Cargo - Nanotechnology

What is Cargo in Nanotechnology?

In the realm of nanotechnology, "cargo" refers to the molecular or nanoscale materials that are transported by nanocarriers. These cargoes can include drugs, genes, proteins, or other therapeutic agents designed for delivery to specific cells or tissues. The goal is to enhance the efficacy and targeting of treatments, often with reduced side effects compared to traditional methods.

How is Cargo Transported?

Cargo transportation in nanotechnology involves the use of nanocarriers such as liposomes, dendrimers, nanoemulsions, and carbon nanotubes. These carriers are engineered to encapsulate, protect, and deliver the cargo to its intended destination. Various mechanisms like endocytosis and passive targeting are employed to facilitate the delivery process.

What are the Applications of Cargo in Nanotechnology?

The applications of cargo in nanotechnology span numerous fields, particularly in biomedicine. These include:

Drug Delivery: Enhancing the delivery of pharmaceuticals to specific cells or tissues to improve therapeutic outcomes.
Gene Therapy: Transporting genetic material to correct defective genes or introduce new ones.
Cancer Treatment: Targeting cancer cells specifically to minimize damage to healthy cells.
Diagnostics: Using nanocarriers to deliver contrast agents or markers for improved imaging and diagnosis.

What are the Challenges in Cargo Delivery?

While the potential of nanotechnology cargo is vast, there are several challenges that need to be addressed:

Stability: Ensuring that the nanocarriers and their cargo remain stable during transportation and storage.
Biocompatibility: Avoiding immune responses or toxicity to ensure safety.
Targeting Efficiency: Achieving precise delivery to the intended cells or tissues.
Scale-Up: Developing methods to produce nanocarriers and cargo on a large scale for commercial use.

Future Directions

Research in nanotechnology is continually evolving, with a focus on overcoming existing challenges and expanding applications. Innovations such as smart nanocarriers that can respond to environmental stimuli and advancements in nanomedicine are paving the way for more effective and personalized treatments. Collaborative efforts between scientists, engineers, and clinicians are essential to translating these technologies from the lab to the clinic.

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Isolation and Characterization of Extracellular Vesicles to Activate Retina Regeneration.

Issue Release: 2025

Proteomic profiling of mesenchymal stem cell-derived extracellular vesicles: Impact of isolation methods on protein cargo.

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TM4SF1 is a molecular facilitator that distributes cargo proteins intracellularly in endothelial cells in support of blood vessel formation.

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Exosomes in Bone Cancer: Unveiling their Vital Role in Diagnosis, Prognosis, and Therapeutic Advancements.

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Enhancing circulatory myokines and extracellular vesicle uptake with targeted exercise in patients with prostate cancer (the MYEX trial): a single-group crossover study.

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A force-sensitive mutation reveals a non-canonical role for dynein in anaphase progression.

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Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration.

Issue Release: 2024

Recent advances in chemical biology tools for protein and RNA profiling of extracellular vesicles.

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Extracellular Vesicles in Cardiovascular Pathophysiology: Communications, Biomarkers, and Therapeutic Potential.

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Long non-coding RNAs as pathophysiological regulators, therapeutic targets and novel extracellular vesicle biomarkers for the diagnosis of inflammatory bowel disease.

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Role of mesenchymal stem cell-derived exosomes in the regeneration of different tissues.

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Tumor-associated macrophages derived exosomes; from pathogenesis to therapeutic opportunities.

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Assembly and fission of tubular carriers mediating protein sorting in endosomes.

Issue Release: 2024

Sparsely PEGylated poly(beta-amino ester) polyplexes enhance antigen specific T-cell response of a bivalent SARS-CoV-2 DNA vaccine.

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Microfluidic production, stability and loading of synthetic giant unilamellar vesicles.

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Role of aptamer technology in extracellular vesicle biology and therapeutic applications.

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Cell-penetrating peptides for sustainable agriculture.

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