What is Biodistribution in Nanotechnology?
Biodistribution refers to the distribution of substances, such as
nanoparticles, within a biological system. In the context of nanotechnology, it is critical to understand how these nanoparticles travel through the body, where they accumulate, and how they are excreted. This knowledge helps in assessing the
efficacy and
safety of nano-based drug delivery systems.
Challenges in Biodistribution Studies
Conducting biodistribution studies comes with several challenges. One major challenge is the
heterogeneity of biological systems, which can lead to variable results. Additionally, the
complexity of nanoparticle formulations can make it difficult to predict their behavior in vivo. There is also the issue of
immunogenicity, where nanoparticles may trigger an immune response, affecting their distribution.
